Maybe ketamine would help?

From Aug 19, 2010 Scientific American:

Ketamine—a powerful anesthetic for humans and animals that lists hallucinations among its side effects and therefore is often abused under the name Special K—delivers rapid relief to chronically depressed patients, and researchers may now have discovered why. In fact, the latest evidence reinforces the idea that the psychedelic drug could be the first new drug in decades to lift the fog of depression.

“We were trying to figure out what ketamine was doing to produce this rapid response,” which can take as little as two hours to begin to act, says neuroscientist Ron Duman of the Yale University School of Medicine. So Duman and his colleagues gave a small amount of ketamine (10 milligrams per kilogram of body weight) to rats and watched the drug literally transform the animals’ brains. “Ketamine… can induce a rapid increase in connections in the brain, the synapses by which neurons interact and communicate with each other, ” Duman says. “You can visually see this response that occurs in response to ketamine.”

More specifically, as the researchers report in the August 20 issue of Science, ketamine seems to stimulate a biochemical pathway in the brain (known as mTOR) to strengthen synapses in a rat’s prefrontal cortex—the region of the brain associated with thinking and personality in humans. And the ketamine helped rats cope with the depression analog experience brought on by forcing the rodents to swim or exposing them to inescapable stress. “Preclinical and clinical studies show that repeated stress or depression can cause a decrease in connections and an atrophy of connections in the same region of the brain,” Duman explains, noting that magnetic resonance imaging shows that some depressed patients have a smaller prefrontal cortex as a result. “Ketamine has the opposite effect and can oppose or reverse the effects of depression” for roughly seven days per dose.

More: Scientific American

In a time of great need—starvation, privation, aggravation, a broken heart and a broken head—I found succor at Dollywood.

SILLY BEASTS IN SACRED PLACES
Karin Bolender on the secret truths that Dollywood reveals

As published in Arthur No. 8 (available from the Arthur Store), with illustrations by Emily Ryan and art direction by W.T. Nelson

. . . And me astride a mighty rooster, with a raging red crown and swelled breast and silver claws, and it running, running: but suspended, rising and falling slow like tides, like a horse in a dream who gallops without going anywhere-rising and falling with hydraulic and dreamlike monotony, round and round, the same dim motion ascribing its circumference of colored lights and warped music round and again like a lathe into the world’s great big empty bowl. The next time around, it was a goat I rode. (1)

Oh it may have all started way back, when I was nine and saw a unicorn while on a honeymoon in Mexico. It was 1984: the beginning of the end for so many of us, God’s children. Of course nobody believed me. We also saw the Love Boat on that honeymoon, docked in Puerta Vallarta. It was my mother’s second marriage, the real one. But what does it matter now, anyway? That was another age, a virgin country.

And I can tell you, because you already know, how the paths that bring us from childhood to this are crooked and fraught with pitfalls. And this is what we get for our troubles: a soul full of rusty fish hooks and bullet holes, eyes that squint, hands that shake. But there are certain little comforts of adulthood. Whatever your poison happens to be, you seek succor where you can. In a time of great need—starvation, privation, aggravation, a broken heart and a broken head—I found succor at Dollywood.

I suppose I should thank the Bearded Menace, because I never would have discovered Dollywood if he had not smashed up a dream and sent me packing. So it was a fine gift he gave me, in the end. This hotblood from sweethome Georgia who said, “Come on baby, let’s go down south where I am from: I’ll build a mansion in your name, we’ll swim in the black creeks, lay down in the weeds, anywhere we want, lay back on the front porch or on piles of old tires and rock and rock until we are old and wise and ugly to everyone but each other, ourselves. And we’ll hold hands and murmur this dreaming talk with dogs at our feet licking and scratching, rolling in play with our naked children, who will cackle in raucous joy and swing from the scuppernong vines-wild flesh, dying light, faint music wafting in from somewhere. Ripe peaches and pokeberries’ll be washed clean and brought to the porch steps for us by possums and coons. Fruits of the land collected and carried to us by the crows and ants and snakes, who will all gather round in the evening to hear us speak in tongues and sing tales of these very days we are living now and the glory days to come, full of moon-age romance and steamy concupiscence, and don’t forget adventuring, on the sea, in the air, by camelback and purple Triumph: come on baby, let’s go down. Go down with me.”

Back in 1984, when I saw the unicorn in the month of November, I knew that you only have to believe in something enough to make it come true. I knew this because my mama told me, and it was confirmed by Robert Vavra’s 1984 “Unicorns I Have Known” calendar, which advised the following “to the pure of heart: watch carefully entering each forest glade as though you were the first human to set foot there; take time to sample pollen carried on a golden breeze; do not use deodorants or insect repellents or wear leather shoes or belts; and believe. Yes, above all, believe, and you will surely meet as lovely and noble and snow-white a single-horned creature as any who pirouette upon these pages.”

And so I did. All over 1984, I scrawled with the new calligraphy pen that was also a Christmas present that year: “I BeLIeVe! UnICorNS arE ReAl! UniCoRNs LiVe in 83! I [HEART] UNicOrnS!” And almost a year later, on the honeymoon, it came true. Nobody saw it but me. Not even my mother, who was wrapped up in her own love dream in the Mexican jungle, brighter and more free and happy than she had ever been before, or has been ever since.

* * *

“Women are so wise. They have learned how to live unconfused by reality. Impervious to it.” (2)

This comes from William Faulkner. But it might just as easily come from the pages of Dolly Parton’s autobiography, Dolly, if you read between the lines. Or it could be painted like a motto in twenty-foot letters, alongside a gigantic pink butterfly and an even more gigantic image of Dolly herself, all a-sparkle with sequins and high nest of golden hair, on one of the billboards along the highway in northeast Tennessee, advertising how many miles are still to go before the pilgrim shores up at Dollywood.

But of course, that couldn’t be. Because what lies under the however-many square acres of the Dollywood park is not the glitterful attractions and family entertainments that lure people in, but an old organic thing buried beneath. A mighty powerful secret. Primeval, even.

But oh, the unicorn: it’s not that I ever really forgot it, it’s just that after a while, in time, that quarry was overrun with the dream of other beasts-boys and men, but mostly boys. And with pubescence, I began a metamorphosis into a new and strange kind of being myself: some kind of rootless hairy hallucinating mushroom with linguistic and motor skills.

As if the hormones of pubescence themselves are this bewitching and infinitely powerful kind of hallucinogen, the effects of which never quite wear off, and make you hear and see, and more so believe, all sorts of beautiful monstrosities and warped miracles that fall under the rubric of sexlove. Wild imaginings like “I saw a unicorn” get replaced by wilder ones, like “I will love you forever.”

And somewhere along the seam between childhood and this circus that is sexlove, we are supposed to weed out illusions and fantasies and find out what reality is. A dark time is had by all, for a while anyway. But most of us make it out of adolescence somehow, and emerge as more mature human beings with hopes and desires and even, heaven help us, beliefs. Beliefs are great and all, until they stray toward the sayings and doings of other people. Then, we are all screwed. Yes, that’s exactly what we are.

Well, that’s how I got screwed by the Bearded Menace anyway. Hell, you heard what he said! Let’s see you try to not fall in love with somebody who vows, with an avowal disturbingly familiar to the last letter-every pitch and note and rhythmic twang-to work to construct the world newly every moment, build it with words and woods and other raw materials into what he believes it should be, all the forms and lights and glories, that seem to be exactly what you have been longing and working for all this time, and trying to build, alone. Just see if that doesn’t get all your electrical juices flowing. Silly beast, you believed in this—that the words and deeds building up between the two of you were plank-for-plank making something real and solid of a dream, and not just playing around in funhouse mirrors.

Well, when the blue lightning was over down in Georgia, the darkness that followed was profound. I was thinking all this over one evening, lying there alone in twisted sheets, in the fall, in his parent’s attic, when it was dead. That is when it came to me like a startling burst, hovering over the dark filthy futon, in the sheets full of our scabs and little bloodstains left over from the plague of seedticks we had suffered together with our mutts. And the last kiss—a desperate end-kiss. I will tell you. It was something I had never thought of before, but suddenly there it was.
DOLLYWOOD. That’s how it came, a vision, like Jim Morrison’s Indian. Except it was not a figure but a booming sourceless voice that came into my head, out of nowhere, and commanded, “YOU MUST GO TO DOLLYWOOD.”

What? You mean Dolly Parton’s theme park? What the hell?

“NO, NOT HELL, THAT’S TOO EASY. DOLLYWOOD. GO THERE. GET THEE.”

And how can you argue with a booming sourceless voice that commands you to go somewhere, especially when you are no longer welcome where you are, and you have nowhere else in mind to go?
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